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Clinical trial shows remdesivir accelerates recovery from advanced COVID-19 patientsClinical trial shows remdesivir accelerates recovery from advanced COVID-19 patientsClinical trial shows remdesivir accelerates recovery from advanced COVID-19 patientsClinical trial shows remdesivir accelerates recovery from advanced COVID-19 patients
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Daily News Daily News · 30/04/2020
· World

Clinical trial shows remdesivir accelerates recovery from advanced COVID-19 patients

coronavirus drugs/medications USA
japan-coronavirus-masks

Photo: MTI/AP/Eugene Hoshiko

Hospitalized patients with advanced COVID-19 and lung involvement who received remdesivir recovered faster than similar patients who received placebo, according to a release from the U.S. National Institute of Allergy and Infectious Diseases (NIAID) on Wednesday.

The result came out of preliminary data analysis from a randomized, controlled trial involving 1,063 patients, which began on Feb. 21.

Preliminary results indicated that patients who received remdesivir had a 31 percent faster time to recovery than those who received placebo, according to the release.

Specifically, the median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo.

Results also suggested a survival benefit, with a mortality rate of 8 percent for the group receiving remdesivir versus 11.6 percent for the placebo group.

The first participant in the trial was an American who was repatriated after being quarantined on the Diamond Princess cruise ship that docked in Yokohama, Japan.

The patient volunteered to participate in the study at the first study site, the University of Nebraska Medical Center, in February 2020, according to the NIAID.

A total of 68 sites ultimately joined the study, 47 in the United States and 21 in countries in Europe and Asia.

The trial, sponsored by the NIAID, part of the National Institutes of Health, is the first clinical trial launched in the United States to evaluate an experimental treatment for COVID-19.

Gilead Sciences, an American biopharmaceutical company, also announced preliminary results of phase 3 trial of remdesivir in patients with severe COVID-19, showing more than half of patients in both 5-day and 10-day treatment groups were discharged from the hospital after two weeks.

The trial evaluated 5-day and 10-day dosing durations of remdesivir in hospitalized patients with severe COVID-19. The study demonstrated that patients receiving a 10-day treatment course of remdesivir achieved similar improvement in clinical status compared with those taking a 5-day treatment course, according to Gilead Sciences.

“At Day 14, 64.5 percent of patients in the 5-day treatment group and 53.8 percent of patients in the 10-day treatment group achieved clinical recovery,” said the company in a statement.

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Read alsoCoronavirus – Orbán: Restrictions on movement will remain in effect in Budapest and its surrounding areas!

Source: Xinhua

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