Tesamorelin vs MK-677: Which Works Better?
The size of the global growth hormone market is projected to grow from an estimated $5.71 billion in 2025 to $10.18 billion by 2033, according to a recent report.
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Both Tesamorelin and MK-677 fall in the growth hormone secretagogues (GHSs) category. These are the peptides that enable the regulation of the growth hormone (GH). While all GHSs elevate systemic GH level and its downstream effector, insulin-like growth factor 1 (IGF-1), they work differently. In fact, their dosing and administration protocols are significantly different.
Tesamorelin: GHRH Analog
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). GHRH is a naturally occurring hormone that acts directly on the pituitary gland. It causes the release of GH. Tesamorelin stimulates the natural GH-production process with high specificity.
Mechanism
Tesamorelin directly binds to GHRH receptors on the cells of the pituitary gland. This regulates the pulsatile release of GH. In short, it closely mimics the body’s natural physiological patterns.
It is FDA-approved for a specific therapeutic indication: the reduction of deep belly fat in patients with HIV-associated lipodystrophy.
Benefits
Tesamorelin’s action is very precise. This specificity makes it suitable for targeted fat reduction and physiological GH Release.
It is an FDA-approved prescription drug. This means that Tesamorelin can be trusted for safety and efficacy, which makes patients more comfortable in using it. Pharmacists can source premium peptides from Reverse Peptides for research on hormone regulation treatment.
Precautions
Tesamorelin therapy is done with daily subcutaneous injection. This can be a little uncomfortable for some users. This may also lead to reactions, such as redness, pain, or itching at the site.
MK-677 (Ibutamoren): Oral Ghrelin Mimic
MK-677 is commonly known as Ibutamoren. It is a potent, non-peptide, orally active GH secretagogue. It functions as a ghrelin receptor (GHS-R1a).
Mechanism
Ghrelin is the “hunger hormone.” On binding with the ghrelin receptor, MK-677 stimulates the pituitary gland to release GH. This helps in a more sustained elevation of GH and IGF-1 levels in contrast to the pulsatile action of GHRH analogs, such as Tesamorelin.
Benefits
The major pharmaceutical advantage of MK-677 is its oral bioavailability. This eliminates the need for injections.
Clinical trial subjects report broad effects of MK-677 associated with elevated GH and IGF-1. Some of these are improvements in muscle mass (lean body mass), bone mineral density, and sleep quality.
Precautions
MK-677 is still under investigation and not FDA-approved for general therapeutic use.
It may increase appetite due to Ghrelin’s effect, which in turn causes metabolic disruption. It can also increase blood glucose levels and is often linked to a pre-diabetic state or the worsening of existing diabetes, necessitating careful monitoring.
A common, dose-dependent side effect of MK-677 is temporary water retention, which can cause bloating and peripheral edema.
Advances in synthetic peptides for hormone regulation offer a precise approach to managing endocrine system deficiencies and imbalances. These can be extremely helpful in treating growth and metabolic disorders. Precise balancing of hormones allows practitioners to administer targeted treatments to improve fundamental body functions and address complex issues through personalized therapeutic intervention.
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