The ten deadliest pandemics that changed the world forever

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In the history of humanity, almost every century had an epidemic which took millions of people into graves. In many cases, the number of deaths is still unknown because of the sudden and incredibly quick spread of these epidemics. 

Portfolio reported that many worry about the health consequences of the current coronavirus epidemic and started to compare the virus to other ones and major outbreaks that happened in the world. Luckily, due to modern medicine and medical methods, these epidemics do not take as many lives as the ones occurred in the previous centuries where disinfectants and information technology did not exist. 

Plague of Antonine (165–180)

This was history’s first significant pandemic mentioned in remained written documents historians found. The disease was brought into the Roman Empire by soldiers returning from the Middle-East and was named after the family name of Emperor Marcus Aurelius. In the empire, approximately 5–10 million people died of the plague. According to storytellers, the disease disappeared for a short time but reappeared again taking even more lives. 

Plague of Rome, Antonine, disease, Europe
Photo: Wikimedia Commons (Wellcome Collection Gallery)

Plague of Justinian (541–542)

It was a pandemic that afflicted the Byzantine (Eastern Roman) Empire and especially its capital, Constantinople, as well as the Sasanian Empire and port cities around the entire Mediterranean Sea. Until the Black Death, historians referred to this epidemic as the deadliest one; it took away the lives of 25–100 million people. Back in that day, it meant half of the European continent’s residents. 

Plague of Justinian, Europe, disease, pandemic
Photo: Wikimedia Commons by Josse Lieferinxe

The Black Death (1331–1353)

With 75–200 million deaths the Black Death, also known as the Pestilence, the Great Bubonic Plague, the Great Plague or the Plague, or less commonly the Great Mortality or the Black Plague is still the deadliest pandemic that ever happened in history in Europe, the Middle-East, Central Asia and North Africa. Approximately 30–60% of Europe’s residents died because of the epidemic. The disease was caused by a certain oriental rat flea which carried the Yersinia pestis bacteria in from Central Asia. Europe needed 150 years to recover from losing 20 million people. The Black Death entered Hungary around 1349. 

Black Death, plague doctor, Europe, disease, pandemic
Photo: Wikimedia Commons
Black Death, disease, pandemic, Europe
Photo: Wikimedia Commons by Pieter Bruegel

Cocoliztli epidemic (1545–1548)

The cocoliztli outbreak, or, the great pestilence is a term given to millions of deaths in the territory of New Spain in present-day Mexico in the 16th century attributed to one or more illnesses collectively called cocoliztli, a mysterious disease characterised by high fevers and bleeding. Mexico lost 5–15 million people; approximately 80% of its residents in the 16th century. 

Cocolitzli, epidemic, disease
Photo: Wikimedia Commons by Bernardino de Sahagún
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